Research project grant for development of methods to replace, reduce and refine animal experiments (3R)

Please refer to the application form in Prisma in parallel with reading the instructions below, which describe the call-specific content of the application. More information on what to do in practical terms is available in our Guide for applicants Opens in new window..

Language

International experts are involved in the scientific assessment of the applications. To ensure fair and equitable assessment and efficient processing, please therefore complete your application in English (apart from the popular science description, which you must write in Swedish).

Sections of the application

The application form includes the following tabs:

• Descriptive information
• Research description
• Budget and research resources
• Publications
• Administrating organisation
• Participants
• CV

The information we request under each tab is described below.

Descriptive information

Abstract

In the abstract, please describe in brief the following:

• How the project fulfils the requirement for 3R relevance
• What is to be done: purpose and aims
• How the research will be carried out: project organisation, time plan and scientific methods
• What is important about the planned research

The abstract shall provide a summary picture of the purpose and implementation of the research. Please use wording to ensure persons with another subject specialisation can understand the information.

The description may cover a maximum of 1 500 characters including blank spaces. This is approximately one third of one A4 page in Arial, font size 11, single line spacing.

Popular science description

Describe the planned research in such a way that a person who is not a researcher can understand it. Do this by answering the following questions:

• What is the research about?
• Why is it important to research this?
• In what way may the new knowledge be important?
• How is the project relevant for replacing, reducing and/or refining experiments on animals according to the 3R principle?

The popular science description is important when we inform about the research funded by the Swedish Research Council.

The text must be in Swedish and cover a maximum of 2 000 characters including blank spaces. This is approximately half an A4 page in Arial, font size 11, single line spacing.

Other applications or grants

Describe the relationship between the different projects if

1. you are applying for or intend to apply for other grants from the Swedish Research Council
2. you are receiving an ongoing grant from the Swedish Research Council with a grant period that wholly or partly overlaps with the grant you are now applying for
3. there are applications or grants relating to the same project concept/purpose from the Swedish Research Council or other funding bodies (from you or another researcher).

In all cases, you should also justify why you are submitting one or several further applications. If there are no other applications or grants, please state so.

The description may cover a maximum of 2 000 characters including blank spaces. This is approximately half an A4 page in Arial, font size 11, single line spacing.

Research description

Ethical aspects

Legal and formal requirements

State whether the research covers the handling of personal data, or experiments on animals and/or studies involving humans.

If the research covers any of the above, you must also describe/state the approvals and permits your research project requires, and how you plan to obtain these. Describe any other permits that affect your application, such as whether parts of the research will be done in a country other than Sweden. If no approvals or permits are needed, please state so.

The description may cover a maximum of 2 000 characters including blank spaces. This is approximately half an A4 page in Arial, font size 11, single line spacing.

More information is available on the page Conducting ethical research Opens in new window..

Ethical considerations

Reflect on the ethical issues that may arise for your project, and describe these. You must also describe how you plan to address ethical dilemmas that may arise. Please justify why the research should be carried out against the background of the ethical issues you have identified. Examples of issues to reflect on:

• How do your research questions and expected results measure up in relation to the ethical issues?
• What (direct) risks (physical, mental, or integrity) will research persons or animals be exposed to?
• What long-term risks may arise from the research? Is there any risk that the research may be used in a way that is detrimental to animals, nature/the environment, or society (whole or parts of the same) in other respects?
• Is the research expected to contribute to other values over and above the knowledge gain? If so, to whom?
• How do you weigh up the risks (in particular short-term risks) against the value (which is often more long-term) of the research?

If no ethical issues are raised, please justify this. The description may cover a maximum of 4 000 characters including blank spaces. This is approximately one A4 page in Arial, font size 11, single line spacing.

Sex and gender perspectives

Please state whether sex and gender perspectives are applicable in your planned research, and justify your decision. Please note that we are not asking for information about the composition of the research team (men/women). Read more about sex and gender perspectives in research content. Read more about sex and gender perspectives in research content. Opens in new window.

The following applies:

• If you answer “Yes”: Please justify your answer and describe also how you take account of sex and gender perspectives in the research plan. If you have stated that sex and gender perspectives are applicable, but still choose not to include them in your research plan, you will need to justify this here.
• If you answer “No”, and thereby do not consider that sex and gender perspectives are applicable for your planned research, you do not need to justify your decision.

The justification may cover a maximum of 4 000 characters including blank spaces. This is approximately one A4 page in Arial, font size 11, single line spacing.

Research plan

The research plan shall be forward-looking and consist of a brief but complete description of the research task. It may cover a maximum of 10 page-numbered A4 pages in Arial, font size 11, single line spacing and 2.5 cm margins, including references and any images.

The research plan must include the following headings and information, listed in the following order:

• Purpose and aims: State the overall purpose and specific aims of the research project.
• State-of-the-art: Summarise briefly the current research frontier within the field or area covered by the project. State key references.
• Significance and scientific novelty: Describe briefly how the project relates to previous research within the area, and the impact the project may have in the short and long term. Describe also how the project moves forward or innovates the current research frontier.
• Preliminary and previous results: Describe briefly your own previous research and pilot studies within the research area that make it probable that the project will be feasible. If no preliminary results exist, please state this. State also whether the project continues to build on research and scientific results from a grant awarded previously by the Swedish Research Council.
• Project description: Describe the project design under the following headings:
  • Theory and method: Describe the underlying theory and the methods to be applied in order to reach the project goal.
  • Time plan and implementation: Describe summarily the time plan for the project during the grant period, and how the project will be implemented. Describe also any crucial risks or obstacles that may impact on the implementation, and your plan for managing these.
  • Project organisation: Clarify how you and any participating researchers will contribute to the implementation of the project. Explain in particular how the time allocated by you (that is, your activity level) as project leader is suitable for the task, including the relationship with your other research undertakings. Describe and explain the competences and roles of the participating researchers in the project, and also other key persons (including any doctoral students) who are important for the implementation of the project.

• Translational plan: Describe briefly how you (in addition to scientific publication) will work to ensure the results and new methods are disseminated and recognised by the research community as a whole.

Provide the following information also. If a heading is not relevant to your application, please state this under the heading.

• Data analysis and statistics: Modern methods often generate complex data. Describe how you plan to analyse data collected in the project, and the statistical methods you will be using.
• Equipment: Describe the basic equipment you and your team have at your disposal for the project.
• Need for research infrastructure: Specify the project’s need for international and national research infrastructure. If you choose to use other infrastructure that those supported by the Swedish Research Council Opens in new window., and that are thereby open to all, you must justify this (also applies to local research infrastructure).
• International and national collaboration: Describe your own and the team’s collaboration with foreign and Swedish researchers and research teams. State whether you contribute to or refer to international collaboration in your research.
• Independent line of research: If you are working or will be working in a larger group, please clarify how your project relates to the other projects in the group. If you are (continuing) working in the same team as your doctoral or postdoc supervisor, or if you are continuing a project that wholly or partly started during your doctoral or postdoc studies, you must also describe the relationship between your project and the research of your former supervisor.
• Clinical significance: Explain how the results of the project may be transferred into practical clinical use within the area medicine and health.

Relevance

Relevance for 3R is an absolute requirement for the call. State which of the 3Rs you consider to be of the greatest importance in the project, and develop the way in which your project is relevant to and promotes the development of 3R. The qualitative and quantitative effects relating to 3R relevance shall be described.

Examples of qualitative effects may be the following:

• Will the results lead to experiments on animals being replaced, or conducted in a way that causes less suffering to the animals?
• Will the results lead to reduced suffering for the laboratory animals, and/or improved living environments, and if so, how?
• Can the results be used more generally, or are they specific for a limited research area?
• Can the results obtained impact on regulations or be used in the reviews carried out by regional animal ethics committees?
• Are the validity and reproducibility of the methods within the project investigated, and if so, how?

Examples of the quantitative effects may be the following:

• A statement of the number of animals used by the research team currently, and in which way this project will affect the number of animals used in future.
• The number of research animals used within the research area in an international perspective.
• An estimate of the reduction in the number of research animals that would be used, and whether this is more general or specific for a limited research area.
• An estimate of the number of animals (percentage of animals used previously classified as “major”) that could be moved from the “major” category to “moderate”, “minor” or “terminal” (or move down from “moderate” to “minor” or “terminal”).

The description may cover a maximum of 4 000 characters including blank spaces. This is approximately one A4 page in Arial, font size 11.

Budget and research resources

Project personnel

State the activity level (per cent of a full-time equivalent) of all personnel active within the project, that is, you, any other researchers, doctoral students and other personnel. Please also state the salary you are applying for, for yourself and/or other personnel active within the project, both as a percentage of a full-time salary and as actual annual amounts (including social security contributions). Please state the amounts in Swedish krona, rounded to the nearest 1 000 SEK.

Other costs

Describe any other costs of the project (premises costs, running costs and depreciation costs). Please state the amounts in Swedish krona, rounded to the nearest 1 000 SEK.

You may include depreciation costs for equipment to be used in the project, provided that

• the equipment has an economic life of at least three years
• the equipment has an acquisition value above a certain amount
• the need cannot be satisfied through use of national or international infrastructure supported by the Swedish Research Council and thereby open to all.

You may only include the proportion of depreciation costs that corresponds to the use of the equipment in the proposed project, and you may not include depreciation costs for equipment that is wholly funded by other grants. Please contact your administrating organisation for information about what is included in local research infrastructure, acquisition values or how to calculate depreciation costs.

Total cost of the project

Prisma will automatically add up your budget items in a table. The total amount you are applying for shall also include indirect costs. You will have to add these to the table yourself. Here you can also add any additional costs that the project entails (for which you are not seeking funding under this call).

Indirect costs follow the model that your administrating organisation uses. Please contact your administrating organisation if you have any questions about what constitutes indirect and direct costs.

Justification of the budget applied for

Justify briefly each cost applied for in your budget. The description may cover a maximum of 4 000 characters including blank spaces. This is approximately one A4 page in Arial, font size 11, single line spacing.

Other funding

Please state your or any other researcher’s funding for the project over and above what is applied for in this application. Please state the amounts in Swedish krona, rounded to the nearest 1 000 SEK.

Publications

Applicant’s publication list

Please attach your publication list drawn up according to the headings and information below. The list may cover a maximum of 5 page-numbered A4 pages in Arial, font size 11, single line spacing and 2.5 cm margins.

Sort the publications under each heading in reverse chronological order, so that the latest publication is at the top of the list. Please only include articles or equivalent that are published or accepted for publication at the time of applying. The author name order shall be identical to that of the published work. The application cannot be supplemented with publications after the deadline for the call.

1. Selection of publications: List the 10 publications of greatest importance to your application. Describe how you contributed to each publication, and its relevance to the research project described (maximum 4 lines per publication). Highlight your name in bold in the author list.

2. Relevant publications from 2015–2023: In this part, the publications listed under Item 1 shall also be included if they have been published during the period in question. Sort the publications, with your name highlighted in bold in the author list, under each heading (publication type) in the following order:

• Peer-reviewed original articles
• Peer-reviewed conference contributions, the results of which are not included in other publications
• Peer-reviewed edited volumes
• Research review articles
• Peer-reviewed books and book chapters
• Other publications including popular science books/presentations

3. Number of publications: Specify how many publications you have under each heading (type of publication) below.

• Total number of peer-reviewed original articles
• Total number of peer-reviewed research review articles
• Total number of other publications including patents
• Number of peer-reviewed original articles from 2015–2023
• Number of peer-reviewed research review articles from 2015–2023
• Number of other publications including patents from 2015–2023

Please note that no further bibliometric information shall be stated in the application.

Participating researchers’ publication lists

Attach all participating researchers’ publications lists joined up into one file. The list for each researcher shall include the 10 publications that are the most relevant to the research described, and shall cover a maximum of 1 A4 page in Arial, font size 11, single line spacing and 2.5 cm margins. The name of the researcher in question shall be highlighted in bold and also be included in the page header of each list.

Please only include articles or equivalent that are published or accepted for publication at the time of applying. The author name order shall be identical to that of the published work. The application cannot be supplemented with publications after the deadline for the call.

The publications shall be of the types: Peer-reviewed original articles, conference contributions, edited volumes, research review articles, books and book chapters, and other publications including popular science books/presentations.

Administrating organisation

Please state the administrating organisation and project site.

Participants

Here you as applicant may invite other participating researchers and administrators to your application.

CV

Under this tab, please upload your relevant CV information from your personal account in Prisma. Any participating researchers must upload their own CV information to the application.

The following information (where available) must always be included in each CV:

• Education: First, second and third cycle higher education and specialist degrees.
• Work: Current employment (including employment form) and longer relevant employment held, postdoctoral visits (also included as employment if relevant), research exchanges relevant to the research described and any longer interruptions in the research that have impacted on your opportunity to gain merit as a researcher.
• Merits and awards: Docentship/associate professorship, supervisees (postdoctoral and doctoral students; state the number of persons in each category and list the names of the up to 10 most relevant to you), up to 10 of your most relevant grants awarded in competition, up to 10 of your most relevant prizes and awards, and up to 20 other merits relevant to the application.
• Intellectual property rights: For example, patents and open access computer programs developed by you; state up to 10 of your most relevant.

Scientific quality is the fundamental criterion when the Swedish Research Council allocates grants to research. Your application is evaluated in competition with the other applications on the basis of the following evaluation criteria.

Evaluation process

Your application for a research project grant for development of methods to replace, reduce and refine animal experiments (3R), is evaluated by a specialised subject review panel where the members are Swedish and international researchers.

At least four members review and grade your application individually. If extra competence is needed, your application might also be evaluated by an additional, external, reviewer. The entire review panel (not including any external reviewers) then meets at a review panel meeting to discuss and prioritise the applications, and finally to make a proposal for a decision to the Scientific Council for Medicine and Health.

Review panel Opens in new window.

In order to enable more in-depth discussions of applications of higher quality that have a reasonable chance of being funded, the applications that received the lowest grades from the panel members are not discussed in detail at the review panel meeting. Following the grant decision, all applications receive a final statement that includes the review panel’s grading of the application. The applications that have been discussed in more detail at the panel meeting receive an individual final statement which, in addition to the grades, also contains a summary of the review panel’s discussion and joint assessment of the scientific quality of the application.

Here you will find a more comprehensive description of the Swedish Research Council's assessment of applications Opens in new window..

Evaluation criteria and guiding questions

The evaluation of the scientific quality of your application is made based on four basic criteria (Scientific quality of the proposed research, Novelty and originality, Merits of the applicant, Feasibility). The purpose of using several components is to achieve a multi-faceted evaluation. In general, the scientific quality of the project receives a greater focus when evaluating project grant applications. The criteria are assessed on a seven-grade scale, except for feasibility, which is assessed on a three-grade scale.

In addition to the basic criteria, your application is also evaluated using an additional criterion (Relevance) on a seven-grade scale.

For each criterion, there are guiding questions to support the panel members’ evaluation of your application. These can also function as guidance for you when you write your application.

Scientific quality of the proposed research (1–7)

Guiding questions:

• Is the definition of the problems and proposed solutions clear and compelling?
• Do the study design, research questions and hypotheses meet the standard of the highest scientific quality?
• Are the hypotheses clearly defined and based on the appropriate literature and/or preliminary data?
• Are potential problems and alternative strategies identified and presented?
• Are methods, including data analysis and statistics, appropriate for the project and well described?
• Are the ethical considerations for the proposed project described and addressed properly? Does the applicant adequately consider risk/value/suffering for humans, animals, nature and/or society?
• If sex and gender is described as relevant to the research project, has the applicant considered sex and gender in the description of the proposed work, for instance as part of preliminary data, the choice of samples or study population, or data analyses?
• Is the project significant to the development of methods to replace, reduce and/or refine animal experiments?

Novelty and originality (1–7)

Guiding questions:

• Does the project extend or challenge current understanding, opinion or practice in its field?
• Is the project built on a unique combination of ideas, preliminary data, and different methodologies to create novel approaches to address the question at hand?
• Is there potential for creation of new knowledge, novel technologies, or new directions for research and advancement of the field?
• Will completion of the aims improve scientific knowledge, technical capability, and/or clinical practice?
• Does the researcher propose a line of research that has the potential to significantly advance current knowledge in the field or is he/she simply adding details to existing knowledge?

Merits of the applicant (1–7)

Guiding questions:

• Does the applicant have sufficient research experience, expertise, level of independence and scientific network for implementation of the proposed project?
• How do the applicant’s academic qualifications and achievements relate to his or her career age?
• Does the applicant have a documented independent line of investigation?
• Does the publication record suggest a coherent line of investigation? Does the applicant report publications as senior author? Focus is on the most relevant and important publications and reports, with emphasis on quality rather than quantity.

Feasibility (1–3)

Guiding questions:

• Considering the project as a whole, including participating researchers, does the applicant or project group have sufficient competence for completion of the project?
• Is the project leader’s level of activity within the project sufficient with regard to the proposed research plan?
• Is the general design, including the time-frame, realistic for implementing the proposed project?
• Are the materials, methods (including statistics and/or power calculations), experimental models, and when appropriate patient/study cohorts adequate and well adapted to the hypothesis or research question?
• Does the applicant adequately consider relevant legal and formal requirements for the proposed research, such as ethical permits and guidelines?

Overall grade (1–7)

The above subsidiary criteria are weighed together into an overall grade, which reflects the review panel’s joint evaluation of the application’s scientific quality.

Relevance (1-7)

The additional criterion of “relevance” is used by the 3R review panel for applications related to the development of methods for replacing, reducing and/or refining animal experiments. The seven-point grading scale shall be used for this criterion. The “relevance”-criterion must not be weighed into the overall grade. Instead, it is to be weighed into an application’s ranking in relation to others. Thus, an application can be of high relevance, but low scientific quality (or vice versa).

Guiding questions:

• Is this a strategically important 3Rs area?
• Will the proposal replace/reduce animal use by a significant number of animals?
• Will the proposal refine a severe/moderate procedure (even if the number of animals affected is low) OR refine a mild procedure where animal numbers are high?
• Could the outcomes be applicable to other models/research areas?