Karolinska Institutet

Linné Centre for Prevention of Breast and Prostate cancer: CrisP

Granted: 95 MSEK
Contact: Henrik Grönberg
Website:CRisPexternal link, opens in new window

The vision of this Centre is to reduce mortality of breast and prostate cancer through individualized prevention programs. Despite recent successes in the treatment of these diseases the mortality of is still substantial.

The researchers envision that implementation of individual prevention programs will greatly increase the efficacy (lower mortality) and cost-effectiveness (lower expenses, less unnecessary treatments and lower anxiety of the individual). The individualized prevention program will be based on prediction models that identify persons at high risk of developing not only a cancer but also the prognosis of that cancer.

The aims of this Centre are:
• To evaluate all important genetic and environmental risk factors in breast and prostate cancer.
• To identify new genetic prognostic markers in breast and prostate cancer.
• To develop and use risk and progression prediction models in breast and prostate cancer.

  • To develop the field of “Translational Epidemiology" using individual prediction models and implement them in future large-scale targeted prevention programs.

The Centre will be based on the collaborative efforts of 10 scientists, with expertise ranging from Cancer epidemiology, Biostatistics, Molecular Genetics, Genetic Counselling, Breast Imaging, Prostate Cancer Diagnostics, Screening and Cancer Registration, i.e. all essential ingredients for a comprehensive approach to the goals of the Centre.

CERIC – a Linné Center for research on Inflammation and Cardiovascular Disease

Granted: 90 MSEK
Contact: Göran Hansson
Website: CERICexternal link, opens in new window

At CERIC at Karolinska Institutet the researchers will establish a center of excellence for research on inflammation and cardiovascular disease. Its goal is to be an internationally leading center in chronic inflammation, the pathobiological process that links inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and psoriasis with atherosclerotic cardiovascular disease.

For this purpose, the researchers will build on existing, strong research in inflammatory mediators, autoimmunity, chronic inflammatory diseases, and cardiovascular disease at KI. To complement the current PIs, they will invest in recruitments of outstanding young scientists.

Together, the CERIC research team will identify mechanisms of chronic inflammation leading to cardiovascular disease. The following research aims will be addressed:

  • Aim 1. To determine why chronic inflammation sometimes, but not always, results in increased atherosclerosis and leads to myocardial infarction or stroke (cardiovascular disease (CVD)).
  • Aim 2. To identify novel therapy targets and investigate the effects of targeted therapies against CID and CVD.

Taken together, these two approaches will allow us both to understand the etiology and pathogenesis of CID and CVD and provide a basis for improved prevention and therapy for CID and inflammatory CVD, two major challenges to health in the population.

The Human Regenerative Map

Granted: 60 MSEK (10 MSEK to Uppsala University)
Contact: Jonas Frisén
Website: The Human Regenerative Mapexternal link, opens in new window

In the spirit of Carl von Linné, the researchers here will propose to establish a map of cell turnover in the human body in health and disease. This will have significant implications for the understanding of many diverse processes, such as for example human brain function and the development of obesity. Moreover, it will provide knowledge necessary for the development of diagnostics and regenerative therapies in for example neurology, psychiatry, cardiology, obesity and diabetes.

Stem cell research and regenerative medicine aim to replace lost cells. However, the dynamics of cell turnover in most human organs is essentially unknown. Without knowing if a specific cell type is renewed in the healthy or pathological situation, it remains uncertain whether it may be realistic and rational to modulate this process with regenerative therapies.

The researchers have recently devised a novel strategy, by integrating biomedical approaches with recent developments in nuclear physics, which enables establishing the turnover of cells in human tissues. By measuring 14C derived from nuclear bomb tests in DNA, we can retrospectively establish the birth date of cells and directly measure cell turnover and tissue regeneration in humans.

The proposed research environment will create major synergy effects at the universities, result in the recruitment of several new research groups and open up new avenues for scientific research in nuclear physics and its integration with basic biomedical research and its clinical implementation.  

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Updated: 2014-09-10